abstract：OBJECTIVE:To compare available instruments for assessing delirium in critically ill adults that have undergone validity testing and provide clinicians with strategies to incorporate these instruments into clinical practice. DESIGN:Medline (1966-September 2006) was searched using the key words: delirium, cognitive dysf...

journal_title：Intensive care medicine

authors： Devlin JW,Fong JJ,Fraser GL,Riker RR

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To investigate the role of the inducible nitric oxide synthase activation-induced excess nitric oxide formation on the rate of hepatic glucose production during fully resuscitated murine septic shock. DESIGN:Prospective, controlled, randomized animal study. SETTING:University animal research laboratory. SU...

journal_title：Intensive care medicine

authors： Albuszies G,Vogt J,Wachter U,Thiemermann C,Leverve XM,Weber S,Georgieff M,Radermacher P,Barth E

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To describe the beliefs and attitudes of intensive care unit (ICU) nurses toward visiting, visiting hours, and open visiting policies in critical care settings. DESIGN:A descriptive, cross-sectional, multicenter survey. SETTING:Seventeen hospitals in Flanders (Dutch-speaking Belgium), including 30 ICUs. Six...

journal_title：Intensive care medicine

authors： Berti D,Ferdinande P,Moons P

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence and the prognostic significance of microalbuminuria in patients after aneurysmal subarachnoid hemorrhage (SAH). DESIGN:Prospective and observational clinical study. SETTING:Multidisciplinary intensive care unit. PATIENTS:Fifty-one consecutive patients who underwent aneurysm clip...

journal_title：Intensive care medicine

authors： Terao Y,Takada M,Tanabe T,Ando Y,Fukusaki M,Sumikawa K

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Brain death may induce cardiac dysfunction. In potential organ donors measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP) and circulating cardiac troponins T and I (cTnT and cTnI), alone or in combination, are performed to investigate the accuracy of these biomarkers for early diagnosis of le...

journal_title：Intensive care medicine

authors： Nicolas-Robin A,Salvi N,Medimagh S,Amour J,Le Manach Y,Coriat P,Riou B,Langeron O

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. DESIGN:Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. ...

journal_title：Intensive care medicine

authors： Pluess TT,Hayoz D,Berger MM,Tappy L,Revelly JP,Michaeli B,Carpentier YA,Chioléro RL

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of early transcranial Doppler ultrasound (TCD) goal-directed therapy after severe traumatic brain injury initiated before invasive cerebral monitoring is available. DESIGN:Prospective, observational clinical study. SETTING:Surgical intensive care unit, university hospital. PATIEN...

journal_title：Intensive care medicine

authors： Ract C,Le Moigno S,Bruder N,Vigué B

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:There is considerable heterogeneity among randomized trials comparing high-frequency ventilation (HFV) with conventional mechanical ventilation (CMV) in premature neonates with respiratory distress syndrome. We investigated what factors explained differences in outcome among these trials. DESIGN:Meta-regress...

journal_title：Intensive care medicine

authors： Bollen CW,Uiterwaal CS,van Vught AJ

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:To analyse the clinical value of procalcitonin (PCT), C-reactive protein (CRP) and leucocyte count in the diagnosis of paediatric sepsis and in the stratification of patients according to severity. DESIGN:Prospective, observational study. SETTING:Paediatric intensive care unit (PICU). PATIENTS:Ninety-four...

journal_title：Intensive care medicine

authors： Rey C,Los Arcos M,Concha A,Medina A,Prieto S,Martinez P,Prieto B

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that levosimendan increases systemic and intestinal oxygen delivery (DO(2)) and prevents intramucosal acidosis in septic shock. DESIGN:Prospective, controlled experimental study. SETTING:University-based research laboratory. SUBJECTS:Nineteen anesthetized, mechanically ventilated she...

journal_title：Intensive care medicine

authors： Dubin A,Murias G,Sottile JP,Pozo MO,Barán M,Edul VS,Canales HS,Etcheverry G,Maskin B,Estenssoro E

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Ornithine alpha-ketoglutarate (OKG) has proved to be efficient in restoring glutamine (Gln) pools which are strongly depleted in hypercatabolic patients. Since its two components, alpha-ketoglutarate (alphaKG) and ornithine (Orn), give rise to glutamate (Glu), they are both considered as Gln precursors. The ...

journal_title：Intensive care medicine

authors： Cynober L,Lasnier E,Le Boucher J,Jardel A,Coudray-Lucas C

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To characterize hemodynamic changes during experimental aspiration pneumonitis, paying special attention to echocardiographic assessment. DESIGN AND SETTING:Animal study in a university-based research laboratory. SUBJECTS:Fourteen mechanically ventilated New Zealand white rabbits INTERVENTIONS:We instilled...

journal_title：Intensive care medicine

authors： Fraisse A,Bregeon F,Delpierre S,Gaudart J,Payan MJ,Pugin J,Papazian L

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is a well-recognized clinico-neuroradiological transient condition. Early recognition is of paramount importance for prompt control of blood pressure or removal of precipitating factors and treatment of epileptic seizures or status epilepticus. Delay in the...

journal_title：Intensive care medicine

authors： Servillo G,Bifulco F,De Robertis E,Piazza O,Striano P,Tortora F,Striano S,Tufano R

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:Biomarkers allowing accurate early staging of septic shock patients are lacking despite their obvious interest for patient management. Experimental models of septic shock in mouse previously noted a decrease in dendritic cell numbers. The aim of the study was to find a rapid reproducible biological test for a...

journal_title：Intensive care medicine

authors： Guisset O,Dilhuydy MS,Thiébaut R,Lefèvre J,Camou F,Sarrat A,Gabinski C,Moreau JF,Blanco P

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Children with peripheral airways obstruction suffer the negative effects of intrinsic positive end-expiratory pressure: increased work of breathing and difficulty triggering assisted ventilatory support. We examined whether external positive end-expiratory pressure to offset intrinsic positive end-expiratory...

journal_title：Intensive care medicine

authors： Graham AS,Chandrashekharaiah G,Citak A,Wetzel RC,Newth CJ

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether the addition of intrapulmonary percussive ventilation to the usual chest physiotherapy improves gas exchange and lung mechanics in tracheostomized patients. DESIGN AND SETTING:Randomized multicenter trial in two weaning centers in northern Italy. PATIENTS AND PARTICIPANTS:46 tracheost...

journal_title：Intensive care medicine

authors： Clini EM,Antoni FD,Vitacca M,Crisafulli E,Paneroni M,Chezzi-Silva S,Moretti M,Trianni L,Fabbri LM

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Growing evidence suggests that acute respiratory distress syndrome (ARDS) occurring as a consequence of primary (direct) lung injury differs from that resulting from secondary (indirect) lung injury in terms of radiographic appearance, response to interventions, and outcomes. We examined whether there are dif...

journal_title：Intensive care medicine

authors： Parker CM,Heyland DK,Groll D,Caeser M

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:Lung injury is a severe complication of acute pancreatitis that increases the mortality rate of the disease. The pathophysiology of acute pancreatitis has been studied in several experimental models, but the kinetics of pulmonary complications in relation to the pancreatic disease is not completely understood...

journal_title：Intensive care medicine

authors： Morel DR,Frossard JL,Cikirikcioglu B,Tapponnier M,Pastor CM

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To compare the total plasma cortisol values obtained from three widely used immunoassays and a high pressure liquid chromatography (HPLC) technique on samples obtained from patients with sepsis. DESIGN AND SETTING:Observational interventional in the general intensive care unit of a metropolitan hospital PAT...

journal_title：Intensive care medicine

authors： Cohen J,Ward G,Prins J,Jones M,Venkatesh B

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Candidemia is a life-threatening infection in the ICU whose prognosis is highly dependent on the stage at which it is recognized. Procalcitonin (PCT) levels have been shown to accurately distinguish between bacteremia and noninfectious inflammatory states in critically ill patients with clinical signs of sep...

journal_title：Intensive care medicine

authors： Charles PE,Dalle F,Aho S,Quenot JP,Doise JM,Aube H,Olsson NO,Blettery B

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Pressure-volume (PV) curves are recorded after induction of complete muscle paralysis, which may limit their clinical use. The feasibility of recording PV curves without paralysis has not been tested. In 19 patients with acute respiratory distress syndrome (ARDS) and no hemodynamic instability we prospectivel...

journal_title：Intensive care medicine

authors： Decailliot F,Demoule A,Maggiore SM,Jonson B,Duvaldestin P,Brochard L

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from i...

journal_title：Intensive care medicine

authors： Monneret G,Lepape A,Voirin N,Bohé J,Venet F,Debard AL,Thizy H,Bienvenu J,Gueyffier F,Vanhems P

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To evaluate whether soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in CSF can serve as a biomarker for the presence of bacterial meningitis and outcome in patients with this disease. DESIGN:Retrospective study of diagnostic accuracy. SETTING AND PATIENTS:CSF was collected from 92 adults ...

journal_title：Intensive care medicine

authors： Determann RM,Weisfelt M,de Gans J,van der Ende A,Schultz MJ,van de Beek D

更新日期：2006-08-01 00:00:00

abstract：:Streptococcus pneumoniae is responsible for two-thirds of ICU admissions due to community-acquired pneumonia (CAP) and is the leading cause of CAP-related death. Early death is principally due to cardiovascular collapse, whereas late death is associated with hypoxemic respiratory failure. Outcome depends on interactio...

journal_title：Intensive care medicine

authors： Luján M,Gallego M,Rello J

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:Cytokeratin 19 (CK19) is a specific cytoskeletal structure for alveolar epithelium. We hypothesized that the levels of CK19 fragments in bronchoalveolar lavage (BAL) fluid could serve as an index of epithelial injury and as a prognosis marker in patients with acute lung injury (ALI) or acute respiratory distr...

journal_title：Intensive care medicine

authors： Stern JB,Paugam C,Validire P,Adle-Biassette H,Jaffré S,Dehoux M,Crestani B

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:The aim of this prospective study was to evaluate the value of sinus echography results to directly indicate a transnasal puncture in intubated patients with suspicion of nosocomial maxillary sinusitis. DESIGN:prospective clinical investigation. SETTING:medical intensive care unit. PATIENTS:sixty patients ...

journal_title：Intensive care medicine

authors： Vargas F,Bui HN,Boyer A,Bébear CM,Lacher-Fougére S,De-Barbeyrac BM,Salmi LR,Traissac L,Gbikpi-Benissan G,Gruson D,Hilbert G

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:The interchangeability of continuous measurement of cardiac output (CO) with the traditional bolus method in patients after cardiopulmonary bypass (CPB) is uncertain. DESIGN:Prospective observational clinical study. SETTING:A 20-bed surgical ICU at a university hospital. PATIENTS:Fourteen deeply sedated, v...

journal_title：Intensive care medicine

authors： Bendjelid K,Schütz N,Suter PM,Romand JA

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:In contrast to indocyanine green (ICG) blood clearance, the plasma disappearance rate (PDR) of ICG does not require absolute ICG blood concentrations and today can be assessed transcutaneously. In this study, we analyzed the relation between ICG disappearance rate and ICG blood clearance as parameters of live...

journal_title：Intensive care medicine

authors： Sakka SG,van Hout N

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. DESIGN:Prospective, randomized, controlled e...

journal_title：Intensive care medicine

authors： Hauser B,Kick J,Iványi Z,Asfar P,Ehrmann U,Muth CM,Albicini M,Wachter U,Vogt J,Bauer M,Brückner UB,Radermacher P,Bracht H

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To examine whether an appropriately designed combination of an index of ventilatory endurance and the frequency divided by tidal volume ratio (f/VT) provides prognostic information for weaning outcome not offered by any index alone. DESIGN AND SETTING:Prospective study in a multidisciplinary intensive care u...

journal_title：Intensive care medicine

authors： Vassilakopoulos T,Routsi C,Sotiropoulou C,Bitsakou C,Stanopoulos I,Roussos C,Zakynthinos S

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To determine the steady-state trough serum and epithelial lining fluid (ELF) concentrations of teicoplanin 12 mg/kg per day in critically ill patients with ventilator associated pneumonia. DESIGN AND SETTING:Prospective, pharmacokinetic study in the surgical intensive care unit in a university hospital. PAT...

journal_title：Intensive care medicine

authors： Mimoz O,Rolland D,Adoun M,Marchand S,Breilh D,Brumpt I,Debaene B,Couet W

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Based on limited data, Candida sp. isolates from bronchoalveolar lavage (BAL) cultures in immunocompetent patients are thought to be contaminants rather than pathogens. The objective of this study was to determine the clinical significance of Candida sp. isolated from BAL cultures in critically ill trauma pat...

journal_title：Intensive care medicine

authors： Wood GC,Mueller EW,Croce MA,Boucher BA,Fabian TC

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Organophosphate toxicity is the leading cause of morbidity and death in poisoning by insecticides. The clinical symptoms of pesticide toxicity range from the classic cholinergic syndrome to flaccid paralysis and intractable seizures. The mainstays of therapy are atropine, oximes, benzodiazepines and supportiv...

journal_title：Intensive care medicine

authors： Hoffmann U,Papendorf T

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The systemic inflammatory response syndrome (SIRS) may be triggered by endotoxin. Humans have antibodies directed against the core of endotoxin (endotoxin core antibodies, EndoCAb) that appear to be protective following surgery and in sepsis. We hypothesised that children with elevated antibodies to endotoxi...

journal_title：Intensive care medicine

authors： Stephens RCM,Fidler K,Wilson P,Barclay GR,Mythen MG,Dixon GLJ,Turner MW,Klein NJ,Peters MJ

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The Brugada syndrome is a clinical and electrocardiographic familial entity, which may lead to sudden cardiac death. A Brugada pattern ECG may occasionally be caused by conditions such as an overdose of tricyclic antidepressants (TCA). Toxicity of TCA frequently results in the need for critical care support. ...

journal_title：Intensive care medicine

authors： Monteban-Kooistra WE,van den Berg MP,Tulleken JE,Ligtenberg JJM,Meertens JHJM,Zijlstra JG

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To obtain insight into the occurrence of brain death and the potential for brain dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH) in a large neurosurgical serving area (2.1 million inhabi...

journal_title：Intensive care medicine

authors： Kompanje EJO,Bakker J,Slieker FJA,IJzermans JNM,Maas AIR

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:Critical illness increases the tendency to both coagulation and bleeding, complicating anticoagulation for continuous renal replacement therapy (CRRT). We analyzed strategies for anticoagulation in CRRT concerning implementation, efficacy and safety to provide evidence-based recommendations for clinical prac...

journal_title：Intensive care medicine

authors： Oudemans-van Straaten HM,Wester JPJ,de Pont ACJM,Schetz MRC

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to explore trends and changes in sedation practices for mechanically ventilated patients in Danish intensive care units (ICUs) and to compare sedation practices in 1997 and 2003. DESIGN:The study was a follow-up survey with a descriptive and comparative cross-sectional multicenter de...

journal_title：Intensive care medicine

authors： Egerod I,Christensen BV,Johansen L

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of increasing dosages of continuously infused arginine-vasopressin (AVP) on mucosal tissue oxygen tension and oxygen supply in an auto-perfused, innervated jejunal segment in an acute endotoxic porcine model. DESIGN:Prospective, randomized, experimental study. SETTING:University hos...

journal_title：Intensive care medicine

authors： Knotzer H,Maier S,Dünser MW,Hasibeder WR,Hausdorfer H,Brandner J,Torgersen C,Ulmer H,Friesenecker B,Iannetti C,Pajk W

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To examine the relationship of fluid balance and weaning outcomes. METHODS:We prospectively collected demographic, physiological, daily fluid balance (measured inputs minus outputs), and weaning data from 87 mechanically ventilated patients. PATIENTS:We examined 87 patients, a median age of 66 years, APACHE...

journal_title：Intensive care medicine

authors： Upadya A,Tilluckdharry L,Muralidharan V,Amoateng-Adjepong Y,Manthous CA

更新日期：2005-12-01 00:00:00